Remember when House was good, like really good? And now that he's hooked up with Cuddy it's a bit meh. When Bruce Willis and Cybil Shepard ruined Moonlighting by getting together?

Is the loss of sexual tension the death knell for a TV Series, like the writers just throwing in the towel...and is it a bad thing; I don't think we'd still wanting to watch Season 25 of Moonlighting, right?

Give notable examples, exceptions to the rule, characters you pray will never get together, and whatever else you're compelled to DiScuss: